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75 In breast and ovarian cancers, for instance, hypomethylation of the ABCB1 (MDR1) promoter correlates with its overexpression, leading to elevated P-gp levels and enhanced efflux of chemotherapeutic agents, culminating in MDR

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74 In adipose tissue, they enhance lipolysis and decrease lipid accumulation in mature adipocytes, increase mRNA LPL expression in preadipocytes, preventing adipocyte hypertrophy by increasing the number of small adipocytes

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Additional studies are exploring its use in patients already on immunosuppression (e.g., post-kidney transplant), which could broaden eligibility and reduce added risks

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