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Upregulation of oxidative mitochondrial metabolism is an accepted method of resistance to other therapeutic interventions in various diseases, such as pancreatic cancer and acute myeloid leukaemia 67,68

Biomed Pharmacother (2016) 79:15965

NFB signaling pathway The NFB signaling pathway plays a crucial role in regulating oxidative stress in asthma because it is a redox-sensitive transcription factor that modulates inflammatory gene expression in response to oxidative stress

Inefficient metabolism has been shown to lead to the accumulation of metabolic intermediates that can interfere with mitochondrial function and impair the ability to produce ATP

Zou L, Yang K, Yu Y, Wang C, Zhao J, Lu C