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Energy expenditure increases measurably

They have FDA approval

Defective antigen processing correlates with a low level of intracellular glutathione

Intestinal biopsy: this can be used to test the amount of lactase produced by the intestinal lining, however this is rarely conducted solely to test for lactose intolerance but may be carried out to test for coeliac disease (which can produce similar symptoms to lactose intolerance)

Long-Term Safety Questions and Research Gaps Limited Clinical Data Most clinical trials last 12 years

However, due to their weight loss effects, they are also increasingly used for combatting obesity in people who may struggle with weight loss through diet and exercise alone