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BH4 treatment did increase SAM but the difference was only borderline statistically significant [ F (1, 26) = 3.03, p = 0.09

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Infants may present with growth failure, irritability, lethargy, muscle weakness, and frequent respiratory infections, while teens may present with pain in weight-bearing joints like the knees, as well as pain in the back, calves, and thighs

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