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Rare heterozygous loss-of-function variants in the human GLP-1 receptor do not associate with cardiometabolic phenotypes

Prophylactic cholecystectomy and ursodeoxycholic acid are not routinely recommended for GLP-1 users and should only be considered under specialist guidance for specific clinical circumstances unrelated to GLP-1 therapy

Freezing causes irreversible damage to the protein structure, rendering the medication ineffective and unsafe to use

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