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GLP-1RAs may modulate inflammation by reducing circulating pro-inflammatory cytokines such as TNF- and IL-6, which promote proteolysis via the ubiquitin-proteasome pathway [9]
GGT and GCL activity was determined through GGT-Activity Colorimetric Assay Kit (Merck Sigma-Aldrich) and GCL Assay Kit (Real-Gene Labs) respectively, following the protocol detailed by the manufacturer
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When PKA inhibitors were added, the anti-apoptotic effect of GLP-1 was abolished (GLP-1 + Rp-cAMP + MG: 0% early apoptosis, 1.36% late apoptosis
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