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The identification of this protein sparked interest among researchers, who began to explore its potential therapeutic applications beyond the gastrointestinal system

Persistently high levels warrant medical investigation to identify any underlying cause

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Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide