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Abbreviations NPs: Nanoparticles BBB: Bloodbrain barrier CNS: Central nervous system CSF: Blood-cerebrospinal fluid PD: Parkinsons disease AD: Alzheimers disease BCSFB: Bloodcerebrospinal fluid barrier MS: Multiple sclerosis BCRP: Breast cancer resistance protein MRPs: Multidrug resistance-associated proteins ECs: Endothelial cells TJs: Tight junctions AJs: Adherent junctions CAMs: Cell adhesion molecules References Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ

Overexpression efficiency was detected by Western blotting (Supplementary Fig

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