Fucoidan, a group of sulfated polysaccharides from brown algae, acts as an SIRT3 activator, inhibiting cellular senescence and the harmful effects of senescence-associated secretory phenotypes (SASPs) 189,190
Quantification was performed on three slides from each brain blinded to the study groups
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Mutations and damage to mitochondrial DNA can affect the function of oxidative phosphorylation complexes, leading to increased ROS generation