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In current experiment, intra-articular injection of MIA allows for the induction of functional impairments and structural damage resembling OA 34,35

doi: 10.1080/19768354.2024.2347503

This imbalance is hypothesized to contribute to dysfunctions in the reward system, potentially manifesting as anhedonia and other depressive symptoms 45 , a clinical observation that aligns with the psychiatric side effects noted in GLP-1 RAs therapy

Real-world outcomes will only be fully understood once the medication is approved and used more widely

Its stability in gastric and systemic environments makes it a valuable compound for ongoing laboratory research into regenerative mechanisms and cytoprotective processes

Abushamat LA, Reusch JEB