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It is a peptide that stimulates natural hormone production
Tirzepatide, a dual GLP-1 / glucose-dependent insulinotropic polypeptide (GIP) agonist, was superior to semaglutide in reducing HbA 1c and body weight in the SURPASS-2 trial, a phase 3, randomised, open-label trial comparing the efficacy and safety of tirzepatide vs semaglutide once weekly as add-on therapy to metformin in individuals with type 2 diabetes [10]
Gut dysbiosis and increased intestinal permeability (leaky gut) are now considered major contributors to chronic metabolic inflammation
The methylated product 1-MNA has been studied for its own signaling effects, though this thread is less central to the adipose research
Luc JGY, Archer MA, Arora RC, Bender EM, Blitz A, Cooke DT, Elde S, Guy TS, Halpern AL, Harrington C, Hlci TN, Kidane B, Olive JK, Ouzounian M, Stamp N, Vervoort D, Varghese TK, Antonoff MB
References: Baxter, S
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