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In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]
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122 Several other mechanisms have been proposed to explain the effects of lead exposure on subnormal levels of 5-NT
In brief, the development of target identification technology promotes the determination of potential anti-cancer targets of ginkgetin, thereby promoting research on its therapeutic mechanisms and enhancing its druggability
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