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Mynatt RL

Here, we highlight the mechanisms linking T2DM and PD, as well as the links between insulin resistance (IR) and PD patients risk of developing cognitive deficits

Inhibition of DPP4 activity by synthetic inhibitors, such as those used to treat type 2 diabetes, results in suppression of T cell proliferation in vitro and a decrease in antibody production in vivo

It requires ongoing use to maintain its effects and should be part of a comprehensive approach to health that includes lifestyle modifications alongside diet and exercise.

About 1 in 100 patients develops severe constipation requiring prescription laxatives, dose reduction, or discontinuation

Nat Commun 16 , 5672 (2025)