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In the CAA, Glp1r + Chat + neurons were dispersed rostro-caudally between the T1 and L2 segments that contain both SPNs and cholinergic interneurons 36
Many weight loss treatments like semaglutide (Wegovy) and tirzepatide (Mounjaro) mimic these hormones, giving you the same feelings of fullness, even when you're in a calorie deficit
(2021) 33:224759 e6
This matters more on a GLP-1, not less
Furthermore, the distal colon and ileum are home to enteroendocrine cells that predominantly manufacture GLP-1, and it is crucial for controlling blood sugar levels (Wu et al
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