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In another study it was found that after weight loss there is a rise in IGFBP-1 and IGFBP-2, both in children and adults [260, 261]

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Possible signs include jawline prominence, enlarged hands/feet, coarse facial features, and organ enlargement (rare and associated with long-term abuse)

NCI 1R01CA193842-01, 1R01CA193842-06A1, 5R01CA186702-07, 1R01DK1010989-06A1, R01HL135564 and R01CA225231-01

Knocking down ACTL6A had no impact on NRF2 expression (Supplementary Fig 6h)