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This change also affects the activity of ion exchangers, which can cause intracellular and, ultimately, mitochondrial calcium (Ca 2+ ) overload [8]

Common side effects and contraindications (bullet list): Mild injection-site redness, bruising Increased hunger, flushing, water retention Headache, dizziness, nausea Temporary joint discomfort Contraindications: active cancer, uncontrolled diabetes, pregnancy, certain cardiac conditions Long-Term Effects Long-term use of CJC-1295, either alone or in combination with peptides such as Ipamorelin, may cause persistent changes in hormones impacting reproductive health and aging