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Gradual dose escalation and patient counseling may improve tolerability, particularly when initiating GLP-1 receptor agonist therapy [38, 43]

Some collagen peptides with DPP-IV inhibitory activity from different collagenous sources, such as bovine, Atlantic salmon, and barbel fish, have been discovered, thus improving insulin secretion and glucose homeostasis [96, 157]

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(2) intervention (exposure) and comparator: SGLT2 inhibitor or GLP-1 receptor agonist monotherapy versus placebo or metformin as a first-line drug