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Importantly, studies that enhanced BCAA catabolism, such as through the inducible knockout or pharmacological inhibition of BCKDK (a key negative regulator), successfully blunted diastolic dysfunction, cardiac hypertrophy, and myocardial Remodelling in mice with HFpEF 93,95
Wegovys mechanism addresses these metabolic drivers directly, which may help explain why results remain strong even after menopause
These changes reflect the medication's broader effect on your metabolic state, not a direct chemical detection of the drug itself
Moloney, A
Other research reported ghrelin was able to stimulate insulin secretion [89]
[Abstract] Proc Natl Acad Sci U S A
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