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DOI 10.1152/japplphysiol.00945.2010 An angiogenesis (new-blood-vessel) study in cultured cells and a rat blood-flow model

The weight you lose on tirzepatide comes from sustained caloric deficit driven by reduced appetite and slower gastric emptying

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Importantly, unlike CTLA-4 blockade, PD-1/PD-L1 blockade generally results in a more favorable safety profile, which is likely attributable to its more restricted activity [35, 36]

It is FDA approved for treating submental fat (under the chin), but is also used off-label for other treatment areas such as the thighs and buttocks