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These may include injection site reactions such as redness, swelling, or tenderness that resolve within 24 to 48 hours
DOI: 10.18295/squmj.2020.20.01.003
Here, we demonstrate that the effects of cotadutide in reducing body weight and food intake and improving glucose control are predominantly mediated through Glp-1 signalling, whereas its action on the liver to reduce lipid content, drive glycogen flux and improve mitochondrial turnover and function are directly mediated through Gcg signalling
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These findings highlight the urgent need for evidence-based guidance for when GLP-1RAs should be used relative to bariatric surgery in adolescents and young adults, including whether medications are most effective before surgery, after surgery, or as part of combination therapy. Other UTSW researchers who contributed to this study are senior author Sarah Barlow, M.D., M.P.H., Professor of Pediatrics
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