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Glyxambi is not effective in treating type 1 diabetes mellitus or diabetic ketoacidosis
The peptide incorporates two key structural modifications: (i) substitution of alanine with 2-aminoisobutyric acid (Aib) at position 8 , which confers resistance to dipeptidyl peptidase-4 (DPP-4) degradation and extends peptide stability in vivo
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The FDAs green light was based on results from the Phase III CAPItello-291 where the combination cut the risk of disease progression or death by half compared to Faslodex alone
DPP-4 normally degrades incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)
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