Almeida-Santos AC, Novais C, Peixe L, Freitas AR
Because prostaglandins and angiotensins are used to expand the afferent arteries, anti-prostaglandin drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), drugs that have anti angiotensin activity such as angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs) can cause nephrotoxicity in the glomerulus Tubular cell toxicity: tubular cells are exposed to a toxic substance (nephrotoxin)
Retrieved from Baranwal, N., Yu, P
This is not a simple modification of existing peptide structures
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ABCB4 variants were associated with ICP (75%) and chronic liver disease (71.7%), with more severe genotypes correlating with an earlier onset