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In the loading dose group, daily intranasal cobalamin administration led to a rapid rise in total serum vitamin B12 levels, increasing from a median of 230 to 1090 pmol/L within two weeks

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Some studies push this even higher, suggesting 1.6 to 2.3 grams per kilogram of fat-free mass for optimal lean tissue preservation

The RAND American Life Panel is a probability sample-based survey panel of about 11,000 active, regularly interviewed respondents aged 12 and older