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4.4 Pharmacokinetic parameters in beagle dogs after intravenous and intramuscular administration In this part of the experiment, three male and three female beagles were examined for four cycles

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At specified time intervals (0 h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, 48 h), the sample solution (1.5 mL) was withdrawn from the dialysate, after which an equal volume of fresh corresponding solution (1.5 mL) was promptly added back into the dialysate to maintain the overall volume