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Once administered, hydroxocobalamin undergoes conversion in the body to active forms of B12, such as methylcobalamin and adenosylcobalamin
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However, the independent effects of vitamin B12 on IR could not be interpreted from the mentioned trials due to combination therapy
The NO-system modulation by BPC-157 raises a pharmacodynamic concern with non-selective beta-blockers such as propranolol and nadolol, which are prescribed for variceal bleeding prophylaxis [2]
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