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PubMed, Scopus, Embase, Web of Science and Cochrane Central library international databases were searched till September 2021
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The cytoprotective properties of Sp extended to decreased progression of degenerative phenotypes in Drosophila Parkinson model due to retention of redox balance in dopaminergic neurons and maintenance of their architecture
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The peptide disrupted FOXO4-p53 co-localization at PML nuclear bodies, releasing p53 to translocate to the mitochondria and trigger the intrinsic apoptosis pathway (Baar et al., 2017)
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