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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
doi: 10.1371/journal.pone.0193652 252 RimoldiS.TorrecillasS.MonteroD.GiniE.MakolA.Victoria ValdenegroV.et al
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