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They also represent a direct collision between the professional judgment of career FDA scientists and a reconstituted advisory committee whose composition had drawn intense scrutiny before the meeting even opened

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Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven