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In normal subjects, both fat and carbohydrate stimulate GIP secretion from enteroendocrine K cells, which are dispersed in the upper portion of the gastrointestinal tract (duodenum and jejunum)

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Additionally, the study moves beyond simple statistical associations to propose plausible mechanistic pathways through which GLP-1RAs may influence psychiatric outcomes

Nearly half of the patients in the trial (45%) lost 30% of their body weight, a feat typically only possible with surgery