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35, 7, 8 are available in Supplementary Data 1
Semaglutide is a modified version of GLP-1 that has been engineered to resist degradation, giving it a half-life of approximately 7 days
Thus, the cytotoxicity profile of SR18 was evaluated by recruiting HeLa and HEK293 cell lines
Both fall short, however, of the weight loss consistently achieved by injectable therapies
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In contrast, studies have shown that intrahippocampal injection of Tat in mice results in lower expression of claudin-5, indicating Tat-induced alterations in TJ protein expression in CNS microvessels [187]
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