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[4] To clear about 95% of a drug, it usually takes around five half-lives

Some evidence also indicates that certain gut bacteria may themselves serve as a source of glycation products in the intestine

Moscioni D, Morizono H, McCarter RJ, Stern A, Cabrera-Luque J, Hoang A, Sanmiguel J, Wu D, Bell P, Gao GP, Raper SE, Wilson JM, Batshaw ML (2006) Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors

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