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These medications work through multiple mechanismsreducing appetite, slowing digestion, and affecting brain hunger centersproducing weight loss results that were previously only achievable through bariatric surgery

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During molecular dynamic simulations with GLP-1 bound, the N-terminal helix was oriented vertically (black and blue arrows), whereas in the apo-form the ECD N-terminal helix was more dynamic and experienced both open and closed conformations (this is analogous to the suggested ECD dynamics for the glucagon receptor)

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The growing use of GLP-1 drugs in clinical practice makes these findings particularly significant