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These medications are not available over the counter and can only be obtained through a prescription

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These effects are typically most noticeable during the first several weeks, though some degree of altered digestion persists throughout treatment

Nat Clin Pract Gastroenterol Hepatol (2006) 3(7):390407.10.1038/ncpgasthep0528 4 RodgersAEzzatiMVander HoornSLopezADLinRBMurrayCJet alDistribution of major health risks: findings from the Global Burden of Disease study

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The trial was not designed to investigate the mechanism of action of semaglutide on knee osteoarthritis, so mechanistic conclusions cannot be drawn