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Table of Contents What defines non-response to GLP-1 therapy Common causes of poor response Identifying modifiable factors Next-step clinical strategies What Defines Non-Response to GLP-1 Therapy in Practice Patients considered non-responders to GLP-1 therapy typically fail to achieve meaningful reductions in HbA1c or body weight after an adequate trial period

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Relatively, exenatide ER was therefore considered 65% as efficacious as once-weekly semaglutide 1.0 mg at bringing patients to target, while dulaglutide 0.75 mg and 1.5 mg were respectively 79% and 97% as efficacious as once-weekly semaglutide 0.5 mg, and 70% and 87% as efficacious as once-weekly semaglutide 1 mg in bringing patients to an HbA1c of lower than 7.0% (Figs