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In a patient whose biliary excretion is already compromised, that increment is not trivial

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It also functions as a potent antioxidant, protecting the skin from oxidative stress caused by free radicals, which can result in dullness, uneven texture, and early aging

However, it is crucial to note that the lower rate of non-CV death with semaglutide was largely due to fewer infection-related deaths, especially those due to COVID-19, rather than a broad reduction across all non-CV death causes

If a patient has central weight gain, elevated fasting insulin, rising A1C, fatigue, and difficulty losing weight despite reasonable habits, the choice of medication should fit the larger metabolic picture