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Frontiers in pharmacology
Deciphering the molecular determinants of VCs context-dependent anticancer effects may accelerate its rational clinical deployment
The omega-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid serve a role in reducing the resistance of tumor cells to bortezomib by activating the serine synthesis pathway, mitochondrial folate cycle, methionine cycle-associated GSH synthesis and ChaC1-mediated GSH degradation in tumor cells, ultimately promoting GSH degradation (138)
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Gkogkolou P, Sarna M, Sarna T, Paus R, Luger TA, Bhm M
Energy and immune benefits appear fastest among all glutathione IV outcomes, with many recipients noticing changes within 24 to 72 hours after their first infusion
