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Melatonin appears to be safe to take nightly for up to a month or two, but it should not be used long-term unless recommended by your healthcare professional

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doi: 10.1042/BST20120236 115 MacDonaldPEWangXXiaFEl-kholyWTargonskyEDTsushimaRGet al

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Abstract We previously reported that in Arabidopsis, the phytochelatin-mediated metal-detoxification machinery is also essential for organomercurial phenylmercury (PheHg) tolerance

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