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Use once daily, preferably in the evening, for 7 consecutive days as an intensive treatment

Singh J, Dubey RK, Atal CK (1986) Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content

Supplier documentation should be internally consistent

Bouman A, Heineman MJ, Faas MM

Contraindications Absolute contraindications include Wilsons Disease or other copper metabolism disorders, known copper allergy or hypersensitivity, and pregnancy or breastfeeding (no safety data exists for systemic use during these periods)

doi: 10.1016/j.crfs.2022.100419, 62