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When to seek medical advice : Contact your GP or diabetes specialist promptly if you experience: Severe, persistent vomiting or diarrhoea leading to dehydration Severe abdominal pain, particularly if radiating to the back (potential pancreatitis) Signs of hypoglycaemia (if taking insulin or sulphonylureas concurrently) Symptoms of gallbladder problems (pain in the upper right abdomen, fever, yellowing of skin) Any changes in vision (rapid improvement in blood glucose can sometimes worsen diabetic retinopathy) [20] Unexplained persistent nausea beyond the first few weeks If you are planning pregnancy, discuss this with your healthcare provider as GLP-1 RAs are not recommended during pregnancy or breastfeeding

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The effect is sharpest during aerobic exercise, where fat is already the body's primary fuel source

While meaningful, this is roughly one-tenth the weight loss tirzepatide achieves

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