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In 2007, Novo Nordisk developed the once-daily drug liraglutide (Victoza for type 2 diabetes and Saxenda for weight management)
In the overweight/obesity group, NAION occurred in 20 semaglutide users and three non-semaglutide users
This was not Pfizers first or last oral GLP-1 disappointment
Semaglutide has a molecular weight of approximately 4,114 daltons
Both berberine and semaglutide are known to cause digestive issues such as nausea, gas, and changes in bowel habits
References: Kleinman HK, Sosne G
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