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One major problem, however, is that the histopathological diagnosis itself is not based upon the search of a single (or a few), objective, and easily reproducible morphological diagnostic feature(s) but rather, it is born by a constellation of diagnostic criteria whose implementation, meaning, and relative weight considerably vary case by case and is responsible for a worrisome list of diagnostic pitfalls ( Table 1 )
Sometimes a slower titration schedule or lower maintenance dose can improve tolerability whilst preserving therapeutic benefits
However, based on current research data, metabolic factors cannot be ruled out as potential contributing factors
High-quality clinics are straightforward about this
This may redefine future expectations from anti-obesity medications. Dr
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