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Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis

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In the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) outcomes trial, adults with overweight or obesity and established cardiovascular disease but without diabetes had fewer major adverse cardiovascular events with semaglutide than with placebo 14,15

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For perspective, blockbuster drugs like Humira or Keytruda each do $1720B/yr

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Pharmaceutical Version: Not available in Canada (Phase 3 trials ongoing) Clinical Trials: Limited Canadian participation opportunities Research Peptides: Available through specialized Canadian suppliers For context, Eli Lillys development timeline suggests FDA submission in early 2026, with a review period of 6 to 12 months

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