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Prospective trials are warranted to confirm these findings and guide clinical decision-making in this underserved population
Probiotic Lactobacillus plantarum 299v supplementation in patients with major depression in a double-blind, randomized, placebo-controlled trial: a metabolomics study
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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question
Long-term health benefits beyond weight loss Medications like semaglutide and tirzepatide can take some of the struggle out of losing weight and maintaining that change