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Its glucose-lowering and insulinotropic efficacy was superior to that of selective GLP-1 receptor agonists in diet-induced obese and leptin receptor-deficient mice, as well as in monkeys and humans [74]
T3 and T4 help to regulate the amount of energy that is used in the body
The BBB rating is an A, which is the best of the three
Phase 2 trial data (Jastreboff et al., NEJM 2023) identified nausea, vomiting, diarrhoea, and constipation as the most common GI side effects
Statements about absorption rates and pharmacokinetics reference published clinical trial data, which may differ from real-world results
Appetite suppression often accompanies early nausea, creating the desired metabolic signal but sometimes too intensely during the adaptation phase
