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Newly differentiated (nave) leukocytes have TLs similar to those of hematopoietic stem cell progenitors, whereas much shorter telomeres are in mature leukocytes (Kimura et al., 2010)

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Its short sequence Gly-His-Lys binds Cu2+ ions with exceptional affinity through the histidine imidazole ring and the terminal amine, forming the characteristic blue complex

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This results in damage to the DNA strands and activation of the DDR [72]