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"While glutathione is a powerful antioxidant and theoretically could reduce oxidative stress in melanocytes, there is no robust clinical data showing that increasing dietary or supplemental glutathione can reliably prevent or reverse gray hair in humans." The body's regulation of hair pigmentation is complex, he added, and once melanocytes lose their ability to produce pigment, antioxidants alone are unlikely to restore it

Huppke-Brindle Syndrome had previously been associated with mutations in the SLC33A1 gene, but the functional consequences remained poorly understood

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Under the trial product estimand the sponsor reports 11.8% (12.5 kg) versus 2.3% (2.5 kg) with placebo [9]