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Hyperpigmentation: 4% niacinamide reduces melasma severity, and 5% formulations show tone improvement when paired with antioxidants and tranexamic acid

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it comes from community practice, and the rationale usually given (letting NNMT expression reset, avoiding tolerance) has never been demonstrated for this compound

Passive diffusion also occurs throughout the intestinal tract, allowing approximately 1% of oral doses to be absorbed without intrinsic factor

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