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The primary clinical step is an immediate dose de-escalation
10.1016/j.cjca.2012.06.009 27
However, combined, they control over 90% of the GLP-1 market, both globally and in the U.S
10.1021/bi061582l Biochemistry 99 SemakV.SemakovaJ.HalbautL.AsoE.FerrerI.CalpenaA.et al (2012)
The question becomes whether additional efficacy justifies any increase in side effect potential
Cell Penetrating Peptide One obstacle needs to be overcome is the poor penetrating ability of GLP-1 through the intestinal epithelia, since GLP-1 is neither small molecule nor hydrophobic
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