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The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months
Vitamin B12 injections are simple, painless injections
3a) with 2.5 L 0.1% lysolecithin (Sigma, St Louis, MO) in PBS over 5 min using a Hamilton syringe 1710RN (Sigma, St Louis, MO) 69,70
Similarly, high salt intake forces the kidneys to excrete more calcium into the urine
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