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The cellular mechanism by which the releasing hormones affect GH secretion from the somatotrope requires specific signal transduction systems (cAMP and/or calcium influx and/or mobilization of intracellular calcium) and/ or tyrosine kinase(s) and/or nitric oxide (NO)/cGMP
doi: 10.1016/j.chom.2012.10.014 46 ButcherLDden HartogGErnstPBCroweSE
Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease
GLP-1 drugs are indicated for patients with BMI above 25 even without complications, or BMI above 23 with obesity-related conditions such as diabetes, hypertension, or fatty liver disease
Investment in agri/food tech will restart after a lengthy pause: More support around food innovation will reignite private and venture capital investment in agri/food tech, which had been stagnant over the past couple of years
Sci Transl Med 5:209ra151 Finan B, Yang B, Ottaway N et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
